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Phencynonate S-isomer as a eutomer is a novel central anticholinergic drug for anti-motion sickness

To compare and evaluate the differences of stereoselective activity, the binding affinity, metabolism, transport and molecular docking of phencynonate isomers to muscarinic acetylcholine receptor (mAChR) were investigated in this study. The rotation stimulation and locomotor experiments were used to...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Xu, Pingxiang, Liu, Ying, Wang, Liyun, Wu, Yi, Zhou, Xuelin, Xiao, Junhai, Zheng, Jianquan, Xue, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374516/
https://ncbi.nlm.nih.gov/pubmed/30760797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38305-9
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