Loss of BCL9/9l suppresses Wnt driven tumourigenesis in models that recapitulate human cancer

Different thresholds of Wnt signalling are thought to drive stem cell maintenance, regeneration, differentiation and cancer. However, the principle that oncogenic Wnt signalling could be specifically targeted remains controversial. Here we examine the requirement of BCL9/9l, constituents of the Wnt-...

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Publicado no:Nat Commun
Main Authors: Gay, David M., Ridgway, Rachel A., Müller, Miryam, Hodder, Michael C., Hedley, Ann, Clark, William, Leach, Joshua D., Jackstadt, Rene, Nixon, Colin, Huels, David J., Campbell, Andrew D., Bird, Thomas G., Sansom, Owen J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374445/
https://ncbi.nlm.nih.gov/pubmed/30760720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08586-3
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