Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas

Protein disulfide isomerases including PDIA1 are implicated in cancer progression, but underlying mechanisms are unclear. PDIA1 is known to support vascular Nox1 NADPH oxidase expression/activation. Since deregulated reactive oxygen species (ROS) production underlies tumor growth, we proposed that P...

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Bibliografiske detaljer
Udgivet i:Cell Death Dis
Main Authors: De Bessa, Tiphany Coralie, Pagano, Alessandra, Moretti, Ana Iochabel Soares, Oliveira, Percillia Victoria Santos, Mendonça, Samir Andrade, Kovacic, Herve, Laurindo, Francisco Rafael Martins
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374413/
https://ncbi.nlm.nih.gov/pubmed/30760703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1402-y
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