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Insights into base-free OsO(4)-catalyzed aminohydroxylations employing chiral ligands

Attempts to perform the OsO(4)-catalyzed enantioselective base-free aminohydroxylation of β,β-disubstituted enoates are described. Low yields and racemic products were obtained in the presence of standard chiral ligands, suggesting the occurrence of a “Second Cycle” process due to slow hydrolysis of...

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Detalhes bibliográficos
Publicado no:Tetrahedron
Main Authors: Cardon, Joseph M., Coombs, James C., Ess, Daniel H., Castle, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6374041/
https://ncbi.nlm.nih.gov/pubmed/30774161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2019.01.018
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