Ifit1 Protects Against Lipopolysaccharide and D-galactosamine–Induced Fatal Hepatitis by Inhibiting Activation of the JNK Pathway

Treatment of mice with lipopolysaccharide (LPS) and the liver-specific transcriptional inhibitor D-(+)-galactosamine (GalN) induces fatal hepatitis, which is mediated by tumor necrosis factor α (TNF-α) and characterized by massive hepatic apoptosis. Previous studies suggest that GalN increases the s...

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Publicado en:J Infect Dis
Autores principales: Chang, Antao, Chen, Yanan, Shen, Wenzhi, Gao, Ruifang, Zhou, Wei, Yang, Shuang, Liu, Yanhua, Luo, Yunping, Chuang, Tsung-Hsien, Sun, Peiqing, Liu, Chenghu, Xiang, Rong
Formato: Artigo
Lenguaje:Inglês
Publicado: Infectious Diseases Society of America 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373839/
https://ncbi.nlm.nih.gov/pubmed/26459629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv221
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