Human Cytomegalovirus Immediate Early 86-kDa Protein Blocks Transcription and Induces Degradation of the Immature Interleukin-1β Protein during Virion-Mediated Activation of the AIM2 Inflammasome

Secretion of interleukin-1β (IL-1β) represents a fundamental innate immune response to microbial infection that, at the molecular level, occurs following activation of proteolytic caspases that cleave the immature protein into a secretable form. Human cytomegalovirus (HCMV) is the archetypal betaher...

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Pubblicato in:mBio
Autori principali: Botto, Sara, Abraham, Jinu, Mizuno, Nobuyo, Pryke, Kara, Gall, Bryan, Landais, Igor, Streblow, Daniel N., Fruh, Klaus J., DeFilippis, Victor R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2019
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372796/
https://ncbi.nlm.nih.gov/pubmed/30755509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02510-18
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