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Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations

Central players of the adaptive immune system are the groups of proteins encoded in the major histocompatibility complex (MHC), which shape the immune response against pathogens and tolerance to self-peptides. The corresponding genomic region is of particular interest, as it harbors more disease ass...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Manczinger, Máté, Boross, Gábor, Kemény, Lajos, Müller, Viktor, Lenz, Tobias L., Papp, Balázs, Pál, Csaba
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372212/
https://ncbi.nlm.nih.gov/pubmed/30703088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000131
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