Glatiramer acetate persists at the injection site and draining lymph nodes via electrostatically-induced aggregation

Glatiramer acetate (GA) is widely prescribed for the treatment of relapsing-remitting multiple sclerosis, however, the mechanism of action is still not fully understood. We investigated the structural properties of GA and examined alterations to the drug upon injection into the subcutaneous space. F...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Song, Jimmy Y., Larson, Nicholas R., Thati, Sharadvi, Torres-Vazquez, Irma, Martinez-Rivera, Noraida, Subelzu-Aispuru, Natalia J., Leon, Martin A., Rosa-Molinar, Eduardo, Schöneich, Christian, Middaugh, C. Russell, Berkland, Cory J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372117/
https://ncbi.nlm.nih.gov/pubmed/30414463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2018.11.007
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