The Crohn’s Disease Risk Factor IRGM Limits NLRP3 Inflammasome Activation by Impeding Its Assembly and by Mediating Its Selective Autophagy

Several large-scale genome-wide association studies genetically linked IRGM to Crohn’s disease and other inflammatory disorders in which the IRGM appears to have a protective function. However, the mechanism by which IRGM accomplishes this anti-inflammatory role remains unclear. Here, we reveal that...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Mehto, Subhash, Jena, Kautilya Kumar, Nath, Parej, Chauhan, Swati, Kolapalli, Srinivasa Prasad, Das, Saroj Kumar, Sahoo, Pradyumna Kumar, Jain, Ashish, Taylor, Gregory A., Chauhan, Santosh
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372082/
https://ncbi.nlm.nih.gov/pubmed/30612879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2018.11.018
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