Activation of miR-21-Regulated Pathways in Immune Aging Selects against Signatures Characteristic of Memory T Cells

Induction of protective vaccine responses, governed by the successful generation of antigen-specific anti-bodies and long-lived memory T cells, is increasingly impaired with age. Regulation of the T cell proteome by a dynamic network of microRNAs is crucial to T cell responses. Here, we show that ac...

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Pubblicato in:Cell Rep
Autori principali: Kim, Chulwoo, Hu, Bin, Jadhav, Rohit R., Jin, Jun, Zhang, Huimin, Cavanagh, Mary M., Akondy, Rama S., Ahmed, Rafi, Weyand, Cornelia M., Goronzy, Jörg J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6371971/
https://ncbi.nlm.nih.gov/pubmed/30463012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.10.074
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