Empirical evaluation of variant calling accuracy using ultra-deep whole-genome sequencing data

In the design of whole-genome sequencing (WGS) studies, sequencing depth is a crucial parameter to define variant calling accuracy and study cost, with no standard recommendations having been established. We empirically evaluated the variant calling accuracy of the WGS pipeline using ultra-deep WGS...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Kishikawa, Toshihiro, Momozawa, Yukihide, Ozeki, Takeshi, Mushiroda, Taisei, Inohara, Hidenori, Kamatani, Yoichiro, Kubo, Michiaki, Okada, Yukinori
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370902/
https://ncbi.nlm.nih.gov/pubmed/30741997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38346-0
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