The UbL-UBA Ubiquilin4 protein functions as a tumor suppressor in gastric cancer by p53-dependent and p53-independent regulation of p21

Ubiquilin4 (Ubqln4), a member of the UbL-UBA protein family, serves as an adaptor in the degradation of specific substrates via the proteasomal pathway. However, the biological function of Ubqln4 remains largely unknown, especially in cancer. Here, we reported that Ubqln4 was downregulated in gastri...

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Detalhes bibliográficos
Publicado no:Cell Death Differ
Main Authors: Huang, Shengkai, Li, Yan, Yuan, Xinghua, Zhao, Mei, Wang, Jia, Li, You, Li, Yuan, Lin, Hong, Zhang, Qiao, Wang, Wenjie, Li, Dongdong, Dong, Xin, Li, Lanfen, Liu, Min, Huang, Weiyan, Huang, Changzhi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370890/
https://ncbi.nlm.nih.gov/pubmed/29899380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0141-4
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