The UbL-UBA Ubiquilin4 protein functions as a tumor suppressor in gastric cancer by p53-dependent and p53-independent regulation of p21

Ubiquilin4 (Ubqln4), a member of the UbL-UBA protein family, serves as an adaptor in the degradation of specific substrates via the proteasomal pathway. However, the biological function of Ubqln4 remains largely unknown, especially in cancer. Here, we reported that Ubqln4 was downregulated in gastri...

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Pubblicato in:Cell Death Differ
Autori principali: Huang, Shengkai, Li, Yan, Yuan, Xinghua, Zhao, Mei, Wang, Jia, Li, You, Li, Yuan, Lin, Hong, Zhang, Qiao, Wang, Wenjie, Li, Dongdong, Dong, Xin, Li, Lanfen, Liu, Min, Huang, Weiyan, Huang, Changzhi
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370890/
https://ncbi.nlm.nih.gov/pubmed/29899380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0141-4
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