DNase II activated by the mitochondrial apoptotic pathway regulates RIP1-dependent non-apoptotic hepatocyte death via the TLR9/IFN-β signaling pathway

Cell death, including apoptotic and non-apoptotic cell death, is frequently observed in liver disease. Upon activation of the mitochondrial apoptotic pathway, mitochondria release not only apoptogenic cytochrome c but also mitochondrial DNA (mtDNA) into the cytosol. The impact of DNase II, a lysosom...

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Publicat a:Cell Death Differ
Autors principals: Saito, Yoshinobu, Hikita, Hayato, Nozaki, Yasutoshi, Kai, Yugo, Makino, Yuki, Nakabori, Tasuku, Tanaka, Satoshi, Yamada, Ryoko, Shigekawa, Minoru, Kodama, Takahiro, Sakamori, Ryotaro, Tatsumi, Tomohide, Takehara, Tetsuo
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370801/
https://ncbi.nlm.nih.gov/pubmed/29855540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0131-6
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