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Flavones hydroxylated at 5, 7, 3′ and 4′ ameliorate skin fibrosis via inhibiting activin receptor-like kinase 5 kinase activity

Skin fibrosis is mainly characterized by excessive collagen deposition. Studies have recently identified a number of flavonoids with variable structures that have the potency of inhibiting collagen synthesis and thus attenuating organ fibrosis. In this study, we found that flavones with 5, 7, 3′, 4′...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Zhang, Yifan, Wang, Jing, Zhou, Sizheng, Xie, Zhibo, Wang, Chuandong, Gao, Ya, Zhou, Jia, Zhang, Xiaoling, Li, Qingfeng
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370799/
https://ncbi.nlm.nih.gov/pubmed/30741930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1333-7
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