Platelet serotonin aggravates myocardial ischemia/reperfusion injury via neutrophil degranulation

BACKGROUND: Platelets store large amounts of serotonin that they release during thrombus formation or acute inflammation. This facilitates hemostasis and modulates the inflammatory response. METHODS: Infarct size, heart function and inflammatory cell composition were analyzed in mouse models of myoc...

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Detalhes bibliográficos
Publicado no:Circulation
Main Authors: Mauler, Maximilian, Herr, Nadine, Schoenichen, Claudia, Witsch, Thilo, Marchini, Timoteo, Härdtner, Carmen, Koentges, Christoph, Kienle, Korbinian, Ollivier, Véronique, Schell, Maximilian, Dorner, Ludwig, Wippel, Christopher, Stallmann, Daniela, Normann, Claus, Bugger, Heiko, Walther, Paul, Wolf, Dennis, Ahrens, Ingo, Lämmermann, Tim, Ho-Tin-Noé, Benoît, Ley, Klaus, Bode, Christoph, Hilgendorf, Ingo, Duerschmied, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370531/
https://ncbi.nlm.nih.gov/pubmed/30586717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.033942
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