A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

We present an integromic analysis of gene alterations that modulate transforming growth factor β (TGF-β)-Smad–mediated signaling in 9,125 tumor samples across 33 cancer types in The Cancer Genome Atlas (TCGA). Focusing on genes that encode mediators and regulators of TGF-β signaling, we found at lea...

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Publicado no:Cell Syst
Main Authors: Korkut, Anil, Zaidi, Sobia, Kanchi, Rupa S., Rao, Shuyun, Gough, Nancy R., Schultz, Andre, Li, Xubin, Lorenzi, Philip L., Berger, Ashton C., Robertson, Gordon, Kwong, Lawrence N, Datto, Mike, Roszik, Jason, Ling, Shiyun, Ravikumar, Visweswaran, Manyam, Ganiraju, Rao, Arvind, Shelley, Simon, Liu, Yuexin, Ju, Zhenlin, Hansel, Donna, de Velasco, Guillermo, Pennathur, Arjun, Andersen, Jesper B., O’Rourke, Colm J., Ohshiro, Kazufumi, Jogunoori, Wilma, Nguyen, Bao-Ngoc, Li, Shulin, Osmanbeyoglu, Hatice U., Ajani, Jaffer A., Mani, Sendurai A., Houseman, Andres, Wiznerowicz, Maciej, Chen, Jian, Gu, Shoujun, Ma, Wencai, Zhang, Jiexin, Tong, Pan, Cherniack, Andrew D., Deng, Chuxia, Resar, Linda, Weinstein, John N., Mishra, Lopa, Akbani, Rehan
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370347/
https://ncbi.nlm.nih.gov/pubmed/30268436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cels.2018.08.010
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