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An efficient algorithm for systematic analysis of nucleotide strings suitable for siRNA design

BACKGROUND: The "off-target" silencing effect hinders the development of siRNA-based therapeutic and research applications. Existing solutions for finding possible locations of siRNA seats within a large database of genes are either too slow, miss a portion of the targets, or are simply no...

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Detalhes bibliográficos
Main Authors: Baranova, Ancha, Bode, Jonathan, Manyam, Ganiraju, Emelianenko, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3117723/
https://ncbi.nlm.nih.gov/pubmed/21619643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-0500-4-168
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