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Hexameric helicase G40P unwinds DNA in single base pair steps

Most replicative helicases are hexameric, ring-shaped motor proteins that translocate on and unwind DNA. Despite extensive biochemical and structural investigations, how their translocation activity is utilized chemo-mechanically in DNA unwinding is poorly understood. We examined DNA unwinding by G4...

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Publicat a:eLife
Autors principals: Schlierf, Michael, Wang, Ganggang, Chen, Xiaojiang S, Ha, Taekjip
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370340/
https://ncbi.nlm.nih.gov/pubmed/30688211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.42001
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