Defects in the alternative splicing-dependent regulation of REST cause deafness

The DNA-binding protein REST forms complexes with histone deacetylases (HDACs) to repress neuronal genes in non-neuronal cells. In differentiating neurons, REST is downregulated predominantly by transcriptional silencing. Here we report that post-transcriptional inactivation of REST by alternative s...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Cell
Main Authors: Nakano, Yoko, Kelly, Michael C., Rehman, Atteeq U., Boger, Erich T., Morell, Robert J., Kelley, Matthew W., Friedman, Thomas B., Bánfi, Botond
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370011/
https://ncbi.nlm.nih.gov/pubmed/29961578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.06.004
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker