Defects in the alternative splicing-dependent regulation of REST cause deafness

The DNA-binding protein REST forms complexes with histone deacetylases (HDACs) to repress neuronal genes in non-neuronal cells. In differentiating neurons, REST is downregulated predominantly by transcriptional silencing. Here we report that post-transcriptional inactivation of REST by alternative s...

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發表在:Cell
Main Authors: Nakano, Yoko, Kelly, Michael C., Rehman, Atteeq U., Boger, Erich T., Morell, Robert J., Kelley, Matthew W., Friedman, Thomas B., Bánfi, Botond
格式: Artigo
語言:Inglês
出版: 2018
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6370011/
https://ncbi.nlm.nih.gov/pubmed/29961578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2018.06.004
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