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β-Branched Amino Acids Stabilize Specific Conformations of Cyclic Hexapeptides

Cyclic peptides (CPs) are a promising class of molecules for drug development, particularly as inhibitors of protein-protein interactions. Predicting low-energy structures and global structural ensembles of individual CPs is critical for the design of bioactive molecules, but these are challenging t...

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Detalles Bibliográficos
Publicado en:Biophys J
Autores principales: Cummings, Ashleigh E., Miao, Jiayuan, Slough, Diana P., McHugh, Sean M., Kritzer, Joshua A., Lin, Yu-Shan
Formato: Artigo
Lenguaje:Inglês
Publicado: The Biophysical Society 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369414/
https://ncbi.nlm.nih.gov/pubmed/30661666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2018.12.015
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