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Crystal structure of the m4-1BB/4-1BBL complex reveals an unusual dimeric ligand that undergoes structural changes upon 4-1BB receptor binding

The interaction between the receptor 4-1BB and its ligand 4-1BBL provides co-stimulatory signals for T-cell activation and proliferation. However, differences in the mouse and human molecules might result in differential engagement of this pathway. Here, we report the crystal structure of mouse 4-1B...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Bitra, Aruna, Doukov, Tzanko, Destito, Giuseppe, Croft, Michael, Zajonc, Dirk M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6369289/
https://ncbi.nlm.nih.gov/pubmed/30545939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006297
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