Crystal structure of murine 4-1BB and its interaction with 4-1BBL support a role for galectin-9 in 4-1BB signaling

4-1BB (CD137) is a TNF receptor superfamily (TNFRSF) member that is thought to undergo receptor trimerization upon binding to its trimeric TNF superfamily ligand (4-1BBL) to stimulate immune responses. 4-1BB also can bind to the tandem repeat–type lectin galectin-9 (Gal-9), and signaling through mou...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Bitra, Aruna, Doukov, Tzanko, Wang, Jing, Picarda, Gaelle, Benedict, Chris A., Croft, Michael, Zajonc, Dirk M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2018
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5787808/
https://ncbi.nlm.nih.gov/pubmed/29242193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.814905
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