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Humanized Mice Reveal New Insights Into the Thymic Selection of Human Autoreactive CD8(+) T Cells
Thymic selection constitutes the first checkpoint in T-cell development to purge autoreactive T cells. Most of our understanding of this process comes from animal models because of the challenges of studying thymopoiesis and how T cell receptor (TCR) specificity impacts thymocyte phenotype in humans...
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| Publicado no: | Front Immunol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6369192/ https://ncbi.nlm.nih.gov/pubmed/30778347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00063 |
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