The arginine methyltransferase PRMT5 and PRMT1 distinctly regulate the degradation of anti-apoptotic protein CFLAR(L) in human lung cancer cells

BACKGROUND: CFLAR(L), also known as c-FLIP(L), is a critical anti-apoptotic protein that inhibits activation of caspase 8 in mammalian cells. Previous studies have shown that arginine 122 of CFLAR(L) can be mono-methylated. However, the precise role of arginine methyltransferase of CFLAR(L) remains...

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Dettagli Bibliografici
Pubblicato in:J Exp Clin Cancer Res
Autori principali: Li, Mingyue, An, Wentao, Xu, Linyan, Lin, Yidan, Su, Ling, Liu, Xiangguo
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368745/
https://ncbi.nlm.nih.gov/pubmed/30736843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1064-8
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