Large-scale production of tauroursodeoxycholic acid products through fermentation optimization of engineered Escherichia coli cell factory

BACKGROUND: Bear bile powder is a valuable medicinal material characterized by high content of tauroursodeoxycholic acid (TUDCA) at a certain ratio to taurochenodeoxycholic acid (TCDCA). We had created an engineered E. coli harboring two-step bidirectional oxidative and reductive enzyme-catalyzing p...

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Bibliographic Details
Published in:Microb Cell Fact
Main Authors: Xu, Yingpeng, Yang, Li, Zhao, Shujuan, Wang, Zhengtao
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368744/
https://ncbi.nlm.nih.gov/pubmed/30736766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-019-1076-2
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