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Hematopoietic Cyclooxygenase-2 Deficiency Increases Adipose Tissue Inflammation and Adiposity in Obesity

OBJECTIVE: Adipose tissue (AT) macrophages mediate AT inflammation in obesity and cyclooxygenase-2 (COX-2) is a major inflammatory gene. We hypothesized that deletion of hematopoietic COX-2 will inhibit AT inflammation in obesity. DESIGN AND METHODS: Lethally irradiated wild type (WT) mice were inje...

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Detalhes bibliográficos
Publicado no:Obesity (Silver Spring)
Main Authors: Adi, Nikhil, Perriotte-Olson, Curtis, Desouza, Cyrus, Ramalingam, Ramesh, Saraswathi, Viswanathan
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6368065/
https://ncbi.nlm.nih.gov/pubmed/26316178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/oby.21184
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