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Enabling precision medicine by unravelling disease pathophysiology: quantifying signal transduction pathway activity across cell and tissue types

Signal transduction pathways are important in physiology and pathophysiology. Targeted drugs aim at modifying pathogenic pathway activity, e.g., in cancer. Optimal treatment choice requires assays to measure pathway activity in individual patient tissue or cell samples. We developed a method enablin...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Stolpe, Anja van de, Holtzer, Laurent, van Ooijen, Henk, de Inda, Marcia Alves, Verhaegh, Wim
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367506/
https://ncbi.nlm.nih.gov/pubmed/30733525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38179-x
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