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Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium
The first step in the development of human colorectal cancer is aberrant activation of the Wnt signaling pathway. Wnt signaling hyperactivation is predominantly caused by loss-of-function mutations in the adenomatous polyposis coli (APC) gene that encodes the pathway negative regulator. In order to...
Enregistré dans:
| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6367488/ https://ncbi.nlm.nih.gov/pubmed/30733598 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38310-y |
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