Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium

The first step in the development of human colorectal cancer is aberrant activation of the Wnt signaling pathway. Wnt signaling hyperactivation is predominantly caused by loss-of-function mutations in the adenomatous polyposis coli (APC) gene that encodes the pathway negative regulator. In order to...

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Autori principali: Horazna, Monika, Janeckova, Lucie, Svec, Jiri, Babosova, Olga, Hrckulak, Dusan, Vojtechova, Martina, Galuskova, Katerina, Sloncova, Eva, Kolar, Michal, Strnad, Hynek, Korinek, Vladimir
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367488/
https://ncbi.nlm.nih.gov/pubmed/30733598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38310-y
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