Exocrine tissue-driven TFF2 prevents apoptotic cell death of endocrine lineage during pancreas organogenesis

During embryogenesis, exocrine and endocrine pancreatic tissues are formed in distinct regions within the branched ductal structure in mice. We previously reported that exocrine-specific inactivation of Pdx1 by Elastase-Cre caused not only hypoplastic exocrine formation but also substantial endocrin...

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Vydáno v:Sci Rep
Hlavní autoři: Hirata, Koji, Kodama, Sota, Nakano, Yasuhiro, Minaki-Nakagawa, Yasuko, Aoyama, Yoshiki, Sakikubo, Morito, Goto, Toshihiko, Yoshida, Masahiro, Masui, Toshihiko, Yamamoto, Takuya, Uemoto, Shinji, Kawaguchi, Yoshiya
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367380/
https://ncbi.nlm.nih.gov/pubmed/30733468
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-38062-9
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