Ptf1a inactivation in adult pancreatic acinar cells causes apoptosis through activation of the endoplasmic reticulum stress pathway

Pancreas transcription factor 1 subunit alpha (PTF1A) is one of the key regulators in pancreatogenesis. In adults, it transcribes digestive enzymes, but its other functions remain largely unknown. Recent conditional knockout studies using Ptf1a(CreER/floxed) heterozygous mouse models have found PTF1...

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Published in:Sci Rep
Main Authors: Sakikubo, Morito, Furuyama, Kenichiro, Horiguchi, Masashi, Hosokawa, Shinichi, Aoyama, Yoshiki, Tsuboi, Kunihiko, Goto, Toshihiko, Hirata, Koji, Masui, Toshihiko, Dor, Yuval, Fujiyama, Tomoyuki, Hoshino, Mikio, Uemoto, Shinji, Kawaguchi, Yoshiya
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6202406/
https://ncbi.nlm.nih.gov/pubmed/30361559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-34093-4
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