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Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene
Insulin-induced gene (Insig) negatively regulates SREBP-mediated de novo fatty acid synthesis in the liver. However, the upstream regulation of Insig is incompletely understood. Here we report that AMPK interacts with and mediates phosphorylation of Insig. Thr222 phosphorylation following AMPK activ...
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| Publicat a: | Nat Commun |
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| Autors principals: | , , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6367348/ https://ncbi.nlm.nih.gov/pubmed/30733434 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08585-4 |
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