Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

Insulin-induced gene (Insig) negatively regulates SREBP-mediated de novo fatty acid synthesis in the liver. However, the upstream regulation of Insig is incompletely understood. Here we report that AMPK interacts with and mediates phosphorylation of Insig. Thr222 phosphorylation following AMPK activ...

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Publicado no:Nat Commun
Main Authors: Han, Yamei, Hu, Zhimin, Cui, Aoyuan, Liu, Zhengshuai, Ma, Fengguang, Xue, Yaqian, Liu, Yuxiao, Zhang, Feifei, Zhao, Zehua, Yu, Yanyan, Gao, Jing, Wei, Chun, Li, Jingya, Fang, Jing, Li, Jia, Fan, Jian-Gao, Song, Bao-Liang, Li, Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6367348/
https://ncbi.nlm.nih.gov/pubmed/30733434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08585-4
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