Chronic hypoxia upregulates DNA methyltransferase and represses large conductance Ca(2+)-activated K(+) channel function in ovine uterine arteries(†)

Chronic hypoxia during gestation suppresses large-conductance Ca(2+)-activated K(+) (BK(Ca)) channel function and impedes uterine arterial adaptation to pregnancy. This study tested the hypothesis that chronic hypoxia has a direct effect in upregulating DNA methyltransferase (DNMT) and epigeneticall...

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Vydáno v:Biol Reprod
Hlavní autoři: Hu, Xiang-Qun, Chen, Man, Dasgupta, Chiranjib, Xiao, Daliao, Huang, Xiaohui, Yang, Shumei, Zhang, Lubo
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Pregnancy
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366546/
https://ncbi.nlm.nih.gov/pubmed/28203702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.116.145946
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