Suppression of Myeloid Cell Arginase Activity leads to Therapeutic Response in a NSCLC Mouse Model by Activating Anti-Tumor Immunity

BACKGROUND: Tumor orchestrated metabolic changes in the microenvironment limit generation of anti-tumor immune responses. Availability of arginine, a semi-essential amino acid, is critical for lymphocyte proliferation and function. Levels of arginine are regulated by the enzymes arginase 1,2 and nit...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Miret, Juan J., Kirschmeier, Paul, Koyama, Shohei, Zhu, Mingrui, Li, Yvonne Y., Naito, Yujiro, Wu, Min, Malladi, Venkat S., Huang, Wei, Walker, William, Palakurthi, Sangeetha, Dranoff, Glenn, Hammerman, Peter S., Pecot, Chad V., Wong, Kwok-Kin, Akbay, Esra A.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6366094/
https://ncbi.nlm.nih.gov/pubmed/30728077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0504-5
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