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Novel Therapeutic Anti-ADAM17 Antibody A9(B8) Enhances EGFR-TKI–Mediated Anticancer Activity in NSCLC

Epidermal growth factor receptor (EGFR) mutations were found in 30%-40% of non–small cell lung cancer (NSCLC) patients, who often responded well to EGFR tyrosine kinase inhibitors (EGFR-TKIs) as exemplified by erlotinib and gefitinib in the past decades. However, EGFR mutation-led drug resistance us...

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Detalhes bibliográficos
Main Authors: Zheng Yang, Kin Iong Chan, Hang Fai Kwok, Kin Yip Tam
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019-11-01
Colecção:Translational Oncology
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1936523319302633
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