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Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

Reactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression has remained incompletely understood. We here show that the transcription factor Stat3 (signal transducer and activator of transcription 3), a canonical inducer of astrogliosis,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:EMBO Mol Med
Hauptverfasser: Reichenbach, Nicole, Delekate, Andrea, Plescher, Monika, Schmitt, Franziska, Krauss, Sybille, Blank, Nelli, Halle, Annett, Petzold, Gabor C
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365929/
https://ncbi.nlm.nih.gov/pubmed/30617153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201809665
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