P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model

Astrocytic hyperactivity is an important contributor to neuronal-glial network dysfunction in Alzheimer’s disease (AD). We have previously shown that astrocyte hyperactivity is mediated by signaling through the P2Y1 purinoreceptor (P2Y1R) pathway. Using the APPPS1 mouse model of AD, we here find tha...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Reichenbach, Nicole, Delekate, Andrea, Breithausen, Björn, Keppler, Kevin, Poll, Stefanie, Schulte, Theresa, Peter, Jan, Plescher, Monika, Hansen, Jan N., Blank, Nelli, Keller, Armin, Fuhrmann, Martin, Henneberger, Christian, Halle, Annett, Petzold, Gabor C.
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987918/
https://ncbi.nlm.nih.gov/pubmed/29724785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171487
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