P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model

Astrocytic hyperactivity is an important contributor to neuronal-glial network dysfunction in Alzheimer’s disease (AD). We have previously shown that astrocyte hyperactivity is mediated by signaling through the P2Y1 purinoreceptor (P2Y1R) pathway. Using the APPPS1 mouse model of AD, we here find tha...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Reichenbach, Nicole, Delekate, Andrea, Breithausen, Björn, Keppler, Kevin, Poll, Stefanie, Schulte, Theresa, Peter, Jan, Plescher, Monika, Hansen, Jan N., Blank, Nelli, Keller, Armin, Fuhrmann, Martin, Henneberger, Christian, Halle, Annett, Petzold, Gabor C.
Format: Artigo
Language:Inglês
Published: Rockefeller University Press 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5987918/
https://ncbi.nlm.nih.gov/pubmed/29724785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20171487
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