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Conformational Changes in a Multidrug Resistance ABC Transporter DrrAB: Fluorescence-based Approaches to Study Substrate Binding
Bacterial multidrug transporter DrrAB exhibits overlapping substrate specificity with mammalian Pglycoprotein. DrrA hydrolyzes ATP, and the energy is transduced to carrier DrrB resulting in export of drugs. Previous studies suggested that DrrB contains a large and flexible drug-binding pocket made o...
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| Vydáno v: | Arch Biochem Biophys |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2018
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6365169/ https://ncbi.nlm.nih.gov/pubmed/30243711 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2018.09.017 |
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