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A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanism

The copper-transporting ATPase ATP7B has an essential role in human physiology, particularly for the liver and brain function. Inactivation of ATP7B is associated with a severe hepatoneurologic disorder, Wilson disease (WD). Hundreds of WD related mutations have been identified in ATP7B to date. The...

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Bibliografiske detaljer
Udgivet i:Metallomics
Main Authors: Schushan, Maya, Bhattacharjee, Ashima, Ben-Tal, Nir, Lutsenko, Svetlana
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365107/
https://ncbi.nlm.nih.gov/pubmed/22692182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2mt20025b
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