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Interactions of fatty acids, nonsteroidal anti-inflammatory drugs, and coxibs with the catalytic and allosteric subunits of cyclooxygenases-1 and -2

Prostaglandin endoperoxide H synthases-1 and -2, commonly called cyclooxygenases-1 and -2 (COX-1 and -2), catalyze the committed step in prostaglandin biosynthesis—the conversion of arachidonic acid to prostaglandin endoperoxide H(2). Both COX isoforms are sequence homodimers that function as confor...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Smith, William L., Malkowski, Michael G.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364783/
https://ncbi.nlm.nih.gov/pubmed/30710016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.TM118.006295
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