Hepatocyte-specific Sirt6 deficiency impairs ketogenesis

Sirt6 is an NADH (NAD(+))-dependent deacetylase with a critical role in hepatic lipid metabolism. Ketogenesis is controlled by a signaling network of hepatic lipid metabolism. However, how Sirt6 functions in ketogenesis remains unclear. Here, we demonstrated that Sirt6 functions as a mediator of ket...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Chen, Lei, Liu, Qinhui, Tang, Qin, Kuang, Jiangying, Li, Hong, Pu, Shiyun, Wu, Tong, Yang, Xuping, Li, Rui, Zhang, Jinhang, Zhang, Zijing, Huang, Ya, Li, Yanping, Zou, Min, Jiang, Wei, Li, Tao, Gong, Meng, Zhang, Lu, Wang, Hua, Qu, Aijuan, Xie, Wen, He, Jinhan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Metabolism
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364758/
https://ncbi.nlm.nih.gov/pubmed/30530497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005309
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