Extended Exposure to Stiff Microenvironments Leads to Persistent Chromatin Remodeling in Human Mesenchymal Stem Cells

Bone marrow derived human mesenchymal stem cells (hMSCs) are a promising cell source for regenerative therapies; however, ex vivo expansion is often required to achieve clinically useful cells numbers. Recent results reveal that when MSCs are cultured in stiff microenvironments, their regenerative c...

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Publicado en:Adv Sci (Weinh)
Autores principales: Killaars, Anouk R., Grim, Joseph C., Walker, Cierra J., Hushka, Ella A., Brown, Tobin E., Anseth, Kristi S.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364489/
https://ncbi.nlm.nih.gov/pubmed/30775233
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/advs.201801483
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