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Nuclear mechanosensing controls MSC osteogenic potential through HDAC epigenetic remodeling
Cells sense mechanical cues from the extracellular matrix to regulate cellular behavior and maintain tissue homeostasis. The nucleus has been implicated as a key mechanosensor and can directly influence chromatin organization, epigenetic modifications, and gene expression. Dysregulation of nuclear m...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7474590/ https://ncbi.nlm.nih.gov/pubmed/32817542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2006765117 |
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