A Human Gain-of-Function STING Mutation Causes Immunodeficiency and Gammaherpesvirus-Induced Pulmonary Fibrosis in Mice

We previously generated STING N153S knock-in mice that have a human disease-associated gain-of-function mutation in STING. Patients with this mutation (STING N154S in humans) develop STING-associated vasculopathy with onset in infancy (SAVI), a severe pediatric autoinflammatory disease characterized...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Bennion, Brock G., Ingle, Harshad, Ai, Teresa L., Miner, Cathrine A., Platt, Derek J., Smith, Amber M., Baldridge, Megan T., Miner, Jonathan J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6364005/
https://ncbi.nlm.nih.gov/pubmed/30463976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01806-18
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