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TCR Retrogenic Mice as a Model to Map Self-Tolerance Mechanisms to the Cancer Mucosa Antigen Guanylyl Cyclase C (GUCY2C)
Characterizing self-tolerance mechanisms and their failure is critical to understand immune homeostasis, cancer immunity, and autoimmunity. However, examination of self-tolerance mechanisms has relied primarily on transgenic mice expressing T-cell receptors (TCRs) targeting well-characterized, but n...
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| Publicado no: | J Immunol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6363846/ https://ncbi.nlm.nih.gov/pubmed/30642983 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1801206 |
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