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A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor
Intramembrane proteolysis of transmembrane substrates by the presenilin–γ-secretase complex is preceded and regulated by shedding of the substrate’s ectodomain by α- or β-secretase. We asked whether β- and γ-secretases interact to mediate efficient sequential processing of APP, generating the amyloi...
Tallennettuna:
| Julkaisussa: | J Cell Biol |
|---|---|
| Päätekijät: | , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
Rockefeller University Press
2019
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6363461/ https://ncbi.nlm.nih.gov/pubmed/30626721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201806205 |
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