Phosphatase Shp2 exacerbates intestinal inflammation by disrupting macrophage responsiveness to interleukin-10

Inflammatory cytokines produced by activated macrophages largely contribute to the pathological signs of inflammatory bowel disease (IBD). Interleukin-10 (IL-10) is the predominant anti-inflammatory cytokine in the intestine, and its therapeutic efficacy for IBD has been clinically tested. Neverthel...

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Udgivet i:J Exp Med
Main Authors: Xiao, Peng, Zhang, Huilun, Zhang, Yu, Zheng, Mingzhu, Liu, Rongbei, Zhao, Yuan, Zhang, Xue, Cheng, Hongqiang, Cao, Qian, Ke, Yuehai
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363431/
https://ncbi.nlm.nih.gov/pubmed/30610104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181198
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