Neuraminidase inhibition contributes to influenza A virus neutralization by anti-hemagglutinin stem antibodies

Broadly neutralizing antibodies (Abs) that bind the influenza virus hemagglutinin (HA) stem may enable universal influenza vaccination. Here, we show that anti-stem Abs sterically inhibit viral neuraminidase (NA) activity against large substrates, with activity inversely proportional to the length o...

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Vydáno v:J Exp Med
Hlavní autoři: Kosik, Ivan, Angeletti, Davide, Gibbs, James S., Angel, Matthew, Takeda, Kazuyo, Kosikova, Martina, Nair, Vinod, Hickman, Heather D., Xie, Hang, Brooke, Christopher B., Yewdell, Jonathan W.
Médium: Artigo
Jazyk:Inglês
Vydáno: Rockefeller University Press 2019
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6363425/
https://ncbi.nlm.nih.gov/pubmed/30683737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181624
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